Research

At NeuroVirt, our work is grounded in the science of neuroplasticity — the brain’s ability to rewire and recover through targeted, repeated movement. Every feature of our platform has been co-designed with clinicians, researchers, and patients to ensure it meets real clinical needs and supports meaningful recovery. By combining scientific rigour with lived experience, we’re creating XR tools that don’t just digitise therapy, but redefine how rehabilitation is delivered and experienced.

Background

Intensive, high-dose therapy is crucial for effective stroke and neurological rehabilitation. Yet many patients receive insufficient rehabilitation dosage due to capacity or time-limited healthcare services  and challenges with adherence to repetitive exercise. Neurotechnology can help increase motivation, engagement, and training intensity- key drivers of neuroplasticity. Since inception, NeuroVirt has been co-designed with patients and clinicians to create a patient-centred and accessible rehabilitation solution, using XR to enhance motivation and support better rehabilitation outcomes.

Study One - Part A

Co-design with stroke patients and clinicians

40 Stroke survivors were recruited from Hobbs Rehabilitation, Jan - Jun 2022. Each participant completed one NeuroVirt session. Participant feedback and therapist observations of sessions with clinical reasoning were recorded. Between sessions, NeuroVirt applied feedback for constant device development and improvement.

Co-design a clinically relevant neurorehabilitation device using immersive virtual reality

Test NeuroVirt's usability, tolerability and acceptability with subacute and chronic stroke survivors

Results


NeuroVirt demonstrated strong usability and acceptability, with participants finding sessions fun and engaging. Therapists noted increased motivation and task intensity, suggesting potential for home and clinic use. No adverse effects occurred. Research shows immersive XR encourages high-repetition, goal-oriented practice that drives neuroplastic change associated with recovery- principles central to NeuroVirt’s design and purpose.

You completely forget about what disability you have, it makes you realise that you can do more than what you think!

- Joyce,82 | Stroke Survivor

Part B - Intensive Rehabilitation Study


Explore potential clinical outcomes of an intensive home-based rehab programme using NeuroVirt with clinical support

One stroke survivor completed six weeks of home-based NeuroVirt (2 hours/day, 6 days/week, alongside standard care) following six weeks of standard care (2× PT/OT weekly plus self-care), with outcome measures evaluated fortnightly.

Results


These exploratory findings highlight that an intensive home-based NeuroVirt programme used alongside standard care can support a higher rehabilitation dose, with early positive changes across key functional indicators. Although based on a single case, these outcomes suggest NeuroVirt’s potential to complement standard care and align with evidence that immersive rehabilitation can enhance engagement and facilitate early functional gains.

ADD LINK TO PAPER HERE

Clinical Feasibility Study


SBRI study ISRCTN54249743

Thirty-six stroke survivors participated in a multi-site, mixed-methods, randomised, assessor-blinded feasibility trial to evaluate home-based upper-limb rehabilitation using NeuroVirt and explore its potential clinical efficacy. All participants completed a personalised six-week home-based programme of upper-limb exercises (6 weeks, 6 days/week, 2 sessions/day, up to 60 minutes each), delivered using either NeuroVirt or a paper-based exercise plan alongside their usual rehabilitation. Follow-up interviews with participants were conducted to evaluate its usability, acceptability, practicality, and explore barriers and facilitators for home use.

Results


These findings show that the NeuroVirt exercise programme was feasible to deliver at home as an adjunct to usual rehabilitation, with strong adherence, high acceptability, safety, and greater rehabilitation dose in the NeuroVirt group. Positive changes/modest improvements on validated clinical measures, together with qualitative feedback from the participants provide valuable insight into its potential clinical efficacy and functional gains, supporting progression to a larger, pragmatic trial to evaluate its clinical and cost-effectiveness across stroke pathways. The gamified and engaging design of NeuroVirt addresses common barriers to exercise adherence, and its portable set-up enables use in real world settings, highlighting its potential to contribute meaningfully to upper-limb recovery when used alongside conventional rehabilitation.

ADD LINK TO PAPER HERE

FUN FACT

NeuroVirt continues to co-design with patients and clinicians. As of mid-2025, NeuroVirt it has been calculated that 500+ patients and 350+ clinicians have been involved in shaping NeuroVirt's tech

I was amazed at how well I could actually use my weaker limb, because I really haven't had the same amount of rehabilitation on my arm and shoulder as I would need. And I think this realy helped me a lot.

-MYRTLE
BRAIN INJURY Survivor

Conclusion

Clinical relevance was ensured throughout device development by regular clinician involvement. Stroke survivors effectively used NeuroVirt with good acceptance and tolerance. Case study results suggest NeuroVirt's potential for clinical efficacy as part of an intensive rehabilitation programme. Larger validation trials are required for generalisability.

TRIAL PARTNERS

Enter your e-mail to download PDF

NeuroVirt Poster

Thank you! Here are the links to download:

NeuroVirt Poster
Oops! Something went wrong while submitting the form.

References:

Hayward, K. S., & Brauer, S. G. (2015). Dose of arm activity training during acute and subacute rehabilitation post stroke: a systematic review of the literature. Clinical rehabilitation, 29(12), 1234–1243. https://doi.org/10.1177/0269215514565395

Henderson A, Korner-Bitensky N, Levin M. (2007) Virtual reality in stroke rehabilitation: a systematic review of its effectiveness for upper limb motor recovery. Topics in stroke rehabilitation.14(2):52-61.

Ioannou, A., Papastavrou, E., Avraamides, M. N., & Charalambous, A. (2020). Virtual Reality and Symptoms Management of Anxiety, Depression, Fatigue, and Pain: A Systematic Review. SAGE Open Nursing. https://doi.org/10.1177/2377960820936163

Kiper, P., Szczudlik, A., Agostini, M., Opara, J., Nowobilski, R., Ventura, L., Tonin, P., & Turolla, A. (2018). Virtual Reality for Upper Limb Rehabilitation in Subacute and Chronic Stroke: A Randomized Controlled Trial. Archives of physical medicine and rehabilitation, 99(5), 834– 842.e4. https://doi.org/10.1016/j.apmr.2018.01.023

Lawrence E. at al., Estimates of the Prevalence of Acute Stroke Impairments and Disability in a Multiethnic Population, 2001. Department of Public Health Medicine. 32(1279-1284)

Mosadeghi, S., Reid, M. W., Martinez, B., Rosen, B. T., & Spiegel, B. M. (2016). Feasibility of an Immersive Virtual Reality Intervention for Hospitalized Patients: An Observational Cohort Study. JMIR mental health, 3(2), e28. https://doi.org/10.2196/mental.5801

Royal College of Physicians: Sentinel Stroke National Audit Programme (SSNAP), Cost & Cost effectiveness analysis, Technical Report, 2016. https://www.strokeaudit.org/Health-Economics.aspx

Worrall L et al., Reducing the psychosocial impact of aphasia on mood and quality of life in people with aphasia and the impact of caregiving in family members through the Aphasia Action Success Knowledge (Aphasia ASK) program: study protocol for a randomized controlled trial. 17(153) (2016). https://doi.org/10.1186/s13063-016-1257-9

Partners:

Backed by:

© NeuroVirt 2025. All rights reserved.